CovidV2, Main, Exploration, bibRecord, 001D25

Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine coronavirus JHM

Identifieur interne : 001D25 ( Main/Exploration ); précédent : 001D24; suivant : 001D26

Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine coronavirus JHM

Auteurs : R. Dörries [Allemagne] ; R. Watanabe [Allemagne] ; H. Wege [Allemagne] ; V. Ter Meulen [Allemagne]

Source :

Journal of Neuroimmunology [ 0165-5728 ] ; 1987.

RBID : ISTEX:0D287B93FF0BD1694B54BFF464DDF6C280566299

Descripteurs français

KwdFr :
- Albumines (), Animaux, Anticorps antiviraux (), Barrière hémato-encéphalique, Encéphalomyélite (anatomopathologie), Encéphalomyélite (immunologie), Immunoglobulines (), Maladies démyélinisantes (immunologie), Rats, Rats de lignée BN, Virus de l'hépatite murine (immunologie).
MESH :
- anatomopathologie : Encéphalomyélite.
- immunologie : Encéphalomyélite, Maladies démyélinisantes, Virus de l'hépatite murine.
- Albumines, Animaux, Anticorps antiviraux, Barrière hémato-encéphalique, Immunoglobulines, Rats, Rats de lignée BN.

English descriptors

KwdEn :
- Albumins (cerebrospinal fluid), Animals, Antibodies, Viral (cerebrospinal fluid), Blood-Brain Barrier, Demyelinating Diseases (immunology), Encephalomyelitis (immunology), Encephalomyelitis (pathology), Immunoglobulins (cerebrospinal fluid), Murine hepatitis virus (immunology), Rats, Rats, Inbred BN.
MESH :
- chemical , cerebrospinal fluid : Albumins, Antibodies, Viral, Immunoglobulins.
- immunology : Demyelinating Diseases, Encephalomyelitis, Murine hepatitis virus.
- pathology : Encephalomyelitis.
Teeft :
- Acta neuropathol, Active demyelination, Animal model, Animals, Antibodies intrathecally, Antibody, Antibody bands, Antibody response, Antibody synthesis, Antibody titres, Antigen expression, Apparent disease, Basic myelin protein, Black arrows, Blood-Brain Barrier, Brain lesions, Brain tissue, Broad pattern, Brown norway, Cerebrospinal fluid, Clonal distribution, Corona virus, Coronavirus, Dako patts, Demyelinating, Demyelinating diseases, Demyelinating encephalomyelitis, Demyelination, Diseased lewis rats, Disproportional increase, Encephalomyelitis, Enzyme immunoassay, Filter area, Glia cells, Immune reaction, Immune response, Immunoglobulin, Infectious process, Inflammatory changes, Inflammatory reactions, Intracerebral spread, Intrathecal, Intrathecal synthesis, Isoelectric distribution, Lesion, Lewis rats, Local production, Meulen, Mild demyelinating encephalomyelitis, Mumps meningitis, Murine, Murine coronavirus, Oligoclonal, Pathogenetic role, Peplomer protein, Perivascular cuffings, Permeability, Persistent infection, Plasma cells, Protein profile, Rat, Rats, Rats, Inbred BN, Serum specimens, Small proteins, Specific antibody indices, Spinal cord, Subacute demyelinating encephalomyelitis, Total immunoglobulin, Varicella zoster meningoencephalitis, Viral, Viral antibodies, Viral antigen, Viral antigens, Viral infections, Virus infection, Virus infections, Virus inoculation, Watanabe, Wege.

Abstract

Abstract: Serum and CSF specimens from clinically healthy Brown Norway (BN) rats inoculated intracerebrally with corona virus JHM were analysed with respect to the state of the blood-brain barrier (BBB) and the intrathecal synthesis and isoelectric distribution of immunoglobulins (Ig). Increased CSF/serum ratios for Ig in the context of an intact BBB were never seen in the absence of intrathecal synthesis of virus-specific antibodies. Affinity-mediated immunoblot analysis revealed a broad pattern of virus-specific antibodies with embedded clusters of restricted heterogeneity, but no signs of oligoclonal Ig production carrying non-viral specificity. From these data it was concluded that BN rats do control the intracerebral spread of JHM virus effectively by a strong local virus-specific antibody response, thereby preventing a clinically apparent disease.

Url:

https://api.istex.fr/ark:/67375/6H6-MV583MTR-C/fulltext.pdf

DOI: 10.1016/0165-5728(87)90017-8

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine coronavirus JHM</title>
<author><name sortKey="Dorries, R" sort="Dorries, R" uniqKey="Dorries R" first="R." last="Dörries">R. Dörries</name>
</author>
<author><name sortKey="Watanabe, R" sort="Watanabe, R" uniqKey="Watanabe R" first="R." last="Watanabe">R. Watanabe</name>
</author>
<author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H." last="Wege">H. Wege</name>
</author>
<author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:0D287B93FF0BD1694B54BFF464DDF6C280566299</idno>
<date when="1987" year="1987">1987</date>
<idno type="doi">10.1016/0165-5728(87)90017-8</idno>
<idno type="url">https://api.istex.fr/ark:/67375/6H6-MV583MTR-C/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000065</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000065</idno>
<idno type="wicri:Area/Istex/Curation">000041</idno>
<idno type="wicri:Area/Istex/Checkpoint">000696</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000696</idno>
<idno type="wicri:doubleKey">0165-5728:1987:Dorries R:analysis:of:the</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:3031130</idno>
<idno type="wicri:Area/PubMed/Corpus">000E01</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E01</idno>
<idno type="wicri:Area/PubMed/Curation">000E01</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E01</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000D80</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D80</idno>
<idno type="wicri:Area/Ncbi/Merge">000818</idno>
<idno type="wicri:Area/Ncbi/Curation">000818</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000818</idno>
<idno type="wicri:doubleKey">0165-5728:1987:Dorries R:analysis:of:the</idno>
<idno type="wicri:Area/Main/Merge">001D47</idno>
<idno type="wicri:Area/Main/Curation">001D25</idno>
<idno type="wicri:Area/Main/Exploration">001D25</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine coronavirus JHM</title>
<author><name sortKey="Dorries, R" sort="Dorries, R" uniqKey="Dorries R" first="R." last="Dörries">R. Dörries</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg</wicri:regionArea>
<orgName type="university">Université de Wurtzbourg</orgName>
<placeName><settlement type="city">Wurtzbourg</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Watanabe, R" sort="Watanabe, R" uniqKey="Watanabe R" first="R." last="Watanabe">R. Watanabe</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg</wicri:regionArea>
<orgName type="university">Université de Wurtzbourg</orgName>
<placeName><settlement type="city">Wurtzbourg</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H." last="Wege">H. Wege</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg</wicri:regionArea>
<orgName type="university">Université de Wurtzbourg</orgName>
<placeName><settlement type="city">Wurtzbourg</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name>
<affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea>Institut für Virologie und Immunobiologie, Universität Würzburg, Versbacher Str. 7, D-8700 Würzburg</wicri:regionArea>
<orgName type="university">Université de Wurtzbourg</orgName>
<placeName><settlement type="city">Wurtzbourg</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Journal of Neuroimmunology</title>
<title level="j" type="abbrev">JNI</title>
<idno type="ISSN">0165-5728</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1987">1987</date>
<biblScope unit="volume">14</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="305">305</biblScope>
<biblScope unit="page" to="316">316</biblScope>
</imprint>
<idno type="ISSN">0165-5728</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0165-5728</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Albumins (cerebrospinal fluid)</term>
<term>Animals</term>
<term>Antibodies, Viral (cerebrospinal fluid)</term>
<term>Blood-Brain Barrier</term>
<term>Demyelinating Diseases (immunology)</term>
<term>Encephalomyelitis (immunology)</term>
<term>Encephalomyelitis (pathology)</term>
<term>Immunoglobulins (cerebrospinal fluid)</term>
<term>Murine hepatitis virus (immunology)</term>
<term>Rats</term>
<term>Rats, Inbred BN</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Albumines ()</term>
<term>Animaux</term>
<term>Anticorps antiviraux ()</term>
<term>Barrière hémato-encéphalique</term>
<term>Encéphalomyélite (anatomopathologie)</term>
<term>Encéphalomyélite (immunologie)</term>
<term>Immunoglobulines ()</term>
<term>Maladies démyélinisantes (immunologie)</term>
<term>Rats</term>
<term>Rats de lignée BN</term>
<term>Virus de l'hépatite murine (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Albumins</term>
<term>Antibodies, Viral</term>
<term>Immunoglobulins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphalomyélite</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Encéphalomyélite</term>
<term>Maladies démyélinisantes</term>
<term>Virus de l'hépatite murine</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Demyelinating Diseases</term>
<term>Encephalomyelitis</term>
<term>Murine hepatitis virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Encephalomyelitis</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Acta neuropathol</term>
<term>Active demyelination</term>
<term>Animal model</term>
<term>Animals</term>
<term>Antibodies intrathecally</term>
<term>Antibody</term>
<term>Antibody bands</term>
<term>Antibody response</term>
<term>Antibody synthesis</term>
<term>Antibody titres</term>
<term>Antigen expression</term>
<term>Apparent disease</term>
<term>Basic myelin protein</term>
<term>Black arrows</term>
<term>Blood-Brain Barrier</term>
<term>Brain lesions</term>
<term>Brain tissue</term>
<term>Broad pattern</term>
<term>Brown norway</term>
<term>Cerebrospinal fluid</term>
<term>Clonal distribution</term>
<term>Corona virus</term>
<term>Coronavirus</term>
<term>Dako patts</term>
<term>Demyelinating</term>
<term>Demyelinating diseases</term>
<term>Demyelinating encephalomyelitis</term>
<term>Demyelination</term>
<term>Diseased lewis rats</term>
<term>Disproportional increase</term>
<term>Encephalomyelitis</term>
<term>Enzyme immunoassay</term>
<term>Filter area</term>
<term>Glia cells</term>
<term>Immune reaction</term>
<term>Immune response</term>
<term>Immunoglobulin</term>
<term>Infectious process</term>
<term>Inflammatory changes</term>
<term>Inflammatory reactions</term>
<term>Intracerebral spread</term>
<term>Intrathecal</term>
<term>Intrathecal synthesis</term>
<term>Isoelectric distribution</term>
<term>Lesion</term>
<term>Lewis rats</term>
<term>Local production</term>
<term>Meulen</term>
<term>Mild demyelinating encephalomyelitis</term>
<term>Mumps meningitis</term>
<term>Murine</term>
<term>Murine coronavirus</term>
<term>Oligoclonal</term>
<term>Pathogenetic role</term>
<term>Peplomer protein</term>
<term>Perivascular cuffings</term>
<term>Permeability</term>
<term>Persistent infection</term>
<term>Plasma cells</term>
<term>Protein profile</term>
<term>Rat</term>
<term>Rats</term>
<term>Rats, Inbred BN</term>
<term>Serum specimens</term>
<term>Small proteins</term>
<term>Specific antibody indices</term>
<term>Spinal cord</term>
<term>Subacute demyelinating encephalomyelitis</term>
<term>Total immunoglobulin</term>
<term>Varicella zoster meningoencephalitis</term>
<term>Viral</term>
<term>Viral antibodies</term>
<term>Viral antigen</term>
<term>Viral antigens</term>
<term>Viral infections</term>
<term>Virus infection</term>
<term>Virus infections</term>
<term>Virus inoculation</term>
<term>Watanabe</term>
<term>Wege</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Albumines</term>
<term>Animaux</term>
<term>Anticorps antiviraux</term>
<term>Barrière hémato-encéphalique</term>
<term>Immunoglobulines</term>
<term>Rats</term>
<term>Rats de lignée BN</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Serum and CSF specimens from clinically healthy Brown Norway (BN) rats inoculated intracerebrally with corona virus JHM were analysed with respect to the state of the blood-brain barrier (BBB) and the intrathecal synthesis and isoelectric distribution of immunoglobulins (Ig). Increased CSF/serum ratios for Ig in the context of an intact BBB were never seen in the absence of intrathecal synthesis of virus-specific antibodies. Affinity-mediated immunoblot analysis revealed a broad pattern of virus-specific antibodies with embedded clusters of restricted heterogeneity, but no signs of oligoclonal Ig production carrying non-viral specificity. From these data it was concluded that BN rats do control the intracerebral spread of JHM virus effectively by a strong local virus-specific antibody response, thereby preventing a clinically apparent disease.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Bavière</li>
<li>District de Basse-Franconie</li>
</region>
<settlement><li>Wurtzbourg</li>
</settlement>
<orgName><li>Université de Wurtzbourg</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Bavière"><name sortKey="Dorries, R" sort="Dorries, R" uniqKey="Dorries R" first="R." last="Dörries">R. Dörries</name>
</region>
<name sortKey="Ter Meulen, V" sort="Ter Meulen, V" uniqKey="Ter Meulen V" first="V." last="Ter Meulen">V. Ter Meulen</name>
<name sortKey="Watanabe, R" sort="Watanabe, R" uniqKey="Watanabe R" first="R." last="Watanabe">R. Watanabe</name>
<name sortKey="Wege, H" sort="Wege, H" uniqKey="Wege H" first="H." last="Wege">H. Wege</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D25 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001D25 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    CovidV2
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:0D287B93FF0BD1694B54BFF464DDF6C280566299
   |texte=   Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine coronavirus JHM
}}

This area was generated with Dilib version V0.6.33.
Data generation: Sat Mar 28 17:51:24 2020. Site generation: Sun Jan 31 15:35:48 2021

Serveur d'exploration Covid (26 mars)

Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine coronavirus JHM

Analysis of the intrathecal humoral immune response in Brown Norway (BN) rats, infected with the murine coronavirus JHM

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration Covid (26 mars)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.